Publications
Development of 3D-printed subcutaneous implants using concentrated polymer/drug solutions. Picco CJ, Utomo E, McClean A, Dominguez-Robles J, Anjani QK, Volpe-Zanuto F, McKenna PE, Acheson J, Malinova D, Donnelly RF, Larraneta E. International Journal of Pharmaceutics, 2023.
The Ins and Outs of Antigen Uptake in B cells. McShane AN, Malinova D. Frontiers in Immunology, 2022.
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs. Picco CJ, Dominguez-Robles J, Utomo E, Paredes AJ, Volpe-Zanutto F, Malinova D, Donnelly RF, Larraneta E. Drug Delivery, 2022.
Endophilin A2 regulates B-cell endocytosis and is required for germinal centre and humoral responses. Malinova D, Wasim L, Newman B, Martinez Riano A, Engels N, Tolar P. EMBO Reports, 2021. e51328.
Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. Ramachandran A, Mehic M, Wasim L, Malinova D, Gori I, Blaszczyk BK, Carvalho DM, Shore EM, Jones C, Hyvonen M, Tolar P, Hill C. EMBO Journal, 2021. 40: e106317.
B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments. Roper SI, Wasim L, Malinova D, Way M, Cox S, Tolar P. Elife, 2019. Dec 9; 8:e48093.
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes, D, Shimaoka M, Springer T, Dustin M, Thrasher A and Burns S. Wellcome Open Research, 2018; 3:84.
Myosin IIa promotes antibody responses by regulating B cell activation, acquisition of antigen and proliferation. Hoogeboom R, Natkanski EM, Nowosad CR, Malinova D, Menon RP, Casal A and Tolar P. Cell Reports, 2018 May 22; 23(8):2342-2353.
Autoinflammatory Periodic Fever, Immunodeficiency and Thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. *Standing ASI, *Malinova D, …, Thrasher AJ, Klein N, Brogan PA. *equal contribution. Journal of Experimental Medicine, 2017; 214(1):59-71.
WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PMG, Blundell MP, Tolar P, Bouma G, Thrasher AJ. Journal of Leukocyte Biology. 2016, 99(5): 699-710.
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1 Record J*, Malinova D*, …, Thrasher A and Burns S. *equal contribution. Blood, 2015, 126(13): 1527-1535.
Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen T, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS, Choudhary C. Molecular systems biology, 2015, 11(6): 810.
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich Syndrome protein and Arp2/3 complex. Poulter NS, Pollitt A, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport J, Hartwig JH, Owen DM, Thrasher AJ, Watson SP and Thomas SG. Nature Communications, 2015, 6:7254.
Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells. Bouma G, Carter NA, Recher M, Malinova D, Adriani M, Notarangelo LD, Burns SO, Mauri C, Thrasher AJ. European Journal of Immunology 2014, 44(9): 2692-2702.
Actin cytoskeletal defects in immunodeficiency. Moulding DA, Record J, Malinova D, Thrasher AJ. Immunological Reviews. 2013, 256(1):282-299.
The Ins and Outs of Antigen Uptake in B cells. McShane AN, Malinova D. Frontiers in Immunology, 2022.
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs. Picco CJ, Dominguez-Robles J, Utomo E, Paredes AJ, Volpe-Zanutto F, Malinova D, Donnelly RF, Larraneta E. Drug Delivery, 2022.
Endophilin A2 regulates B-cell endocytosis and is required for germinal centre and humoral responses. Malinova D, Wasim L, Newman B, Martinez Riano A, Engels N, Tolar P. EMBO Reports, 2021. e51328.
Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. Ramachandran A, Mehic M, Wasim L, Malinova D, Gori I, Blaszczyk BK, Carvalho DM, Shore EM, Jones C, Hyvonen M, Tolar P, Hill C. EMBO Journal, 2021. 40: e106317.
B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments. Roper SI, Wasim L, Malinova D, Way M, Cox S, Tolar P. Elife, 2019. Dec 9; 8:e48093.
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes, D, Shimaoka M, Springer T, Dustin M, Thrasher A and Burns S. Wellcome Open Research, 2018; 3:84.
Myosin IIa promotes antibody responses by regulating B cell activation, acquisition of antigen and proliferation. Hoogeboom R, Natkanski EM, Nowosad CR, Malinova D, Menon RP, Casal A and Tolar P. Cell Reports, 2018 May 22; 23(8):2342-2353.
Autoinflammatory Periodic Fever, Immunodeficiency and Thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. *Standing ASI, *Malinova D, …, Thrasher AJ, Klein N, Brogan PA. *equal contribution. Journal of Experimental Medicine, 2017; 214(1):59-71.
WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PMG, Blundell MP, Tolar P, Bouma G, Thrasher AJ. Journal of Leukocyte Biology. 2016, 99(5): 699-710.
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1 Record J*, Malinova D*, …, Thrasher A and Burns S. *equal contribution. Blood, 2015, 126(13): 1527-1535.
Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen T, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS, Choudhary C. Molecular systems biology, 2015, 11(6): 810.
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich Syndrome protein and Arp2/3 complex. Poulter NS, Pollitt A, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport J, Hartwig JH, Owen DM, Thrasher AJ, Watson SP and Thomas SG. Nature Communications, 2015, 6:7254.
Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells. Bouma G, Carter NA, Recher M, Malinova D, Adriani M, Notarangelo LD, Burns SO, Mauri C, Thrasher AJ. European Journal of Immunology 2014, 44(9): 2692-2702.
Actin cytoskeletal defects in immunodeficiency. Moulding DA, Record J, Malinova D, Thrasher AJ. Immunological Reviews. 2013, 256(1):282-299.
